Adsorption of the Pt(II) anticancer drug carboplatin by mesoporous silica

Chem Biodivers. 2009 Sep;6(9):1343-9. doi: 10.1002/cbdv.200900021.

Abstract

MCM-41, a mesoporous silica nanomaterial with a high surface area for adsorption of small molecules, is a potential new type of delivery vehicle for therapeutic and diagnostic agents. In this report, we show that MCM-41 adsorbs the front-line anticancer drug carboplatin, [Pt(CBDCA-O,O')(NH3)2] (CBDCA=cyclobutane-1,1-dicarboxylate; 1), which is used to treat ovarian, lung, and other types of cancer. UV/Visible difference absorption spectroscopy shows that MCM-41 adsorbs 1.8+/-0.2% of its own weight of carboplatin after a 24 h exposure to 26.9 mM drug in H2O. The pseudo-first-order rate constant for adsorption of carboplatin by MCM-41, measured using [1H,15N] heteronuclear single quantum coherence (HSQC) NMR, and 15N-labeled carboplatin is k(1)=2.92+/-2.17 x 10(-6) s(-1) at ca. 25 degrees.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adsorption
  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / pharmacology
  • Carboplatin / chemistry*
  • Carboplatin / pharmacology
  • Drug Carriers
  • Magnetic Resonance Spectroscopy
  • Silicon Dioxide / chemistry*
  • Spectrophotometry, Ultraviolet

Substances

  • Antineoplastic Agents
  • Drug Carriers
  • MCM-41
  • Silicon Dioxide
  • Carboplatin