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Comparative Study
. 2009 Dec;64(12):1207-11.
doi: 10.1093/gerona/glp134. Epub 2009 Sep 23.

Transplantation of Young Ovaries to Old Mice Increased Life Span in Transplant Recipients

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Free PMC article
Comparative Study

Transplantation of Young Ovaries to Old Mice Increased Life Span in Transplant Recipients

Jeffrey B Mason et al. J Gerontol A Biol Sci Med Sci. .
Free PMC article

Abstract

Previously we reported that prepubertally ovariectomized mice that received young transplanted ovaries at a postreproductive age showed a 40% increase in life expectancy. To study this phenomenon in greater detail, 11-month-old ovariectomized and ovary-intact CBA/J mice underwent ovarian transplantation with 60-day-old ovaries or a sham surgery. Results from observations on transplant recipients in the current study extended our previous results. Whereas intact control mice lived an average of 726 days, transplant recipients lived an average of 770 days (i.e., 780 days for intact recipients and 757 days for ovariectomized recipients). If intact recipients had ceased reproductive cycling by the time of transplant, we observed a further increase in mean life span to 811 days. These results demonstrate that young ovaries enhanced longevity when transplanted to old mice and that ovarian status, examined by means of ovariectomy and ovarian transplantation, clearly influenced the potential of young transplanted ovaries to positively impact longevity.

Figures

Figure 1.
Figure 1.
Experimental design.Note: IT = intact; OX = ovariectomized; S = sham; TX = ovarian transplant.
Figure 2.
Figure 2.
Mean life span (days) in control (IT), combined sham groups (S), and combined transplant recipient groups (TX). Life span of mice in the transplant groups was greater than in the sham groups (770.3 ± 9.7 vs 722.1 ± 12.4, respectively, p = .0029) and tended to be greater than in control mice (725.6 ± 20.4, p = .0538).Notes: OX = ovariectomized. *p = .05, **p < .05, ***p < .005.
Figure 3.
Figure 3.
Mean life span (days) in all groups. Intact transplant mice showed an advantage in life span over ovariectomized sham mice (780.4 ± 14.1 vs 715.0 ± 20.0, respectively, p = .0104), intact sham mice (727.6 ± 15.9, p = .0155), and control mice (725.6 ± 20.4, p = .0310) but not ovariectomized transplant mice (757.1 ± 12.7, p =.2239).Notes: IT = intact; OX = ovariectomized; S = sham; TX = ovarian transplant. *p = .05, **p < .05, ***p < .005.
Figure 4.
Figure 4.
Survival proportion in all groups.Note: IT = intact; OX = ovariectomized; S = sham; TX = ovarian transplant.
Figure 5.
Figure 5.
Mean life span (days) of intact sham and intact transplant mice by cycling status. Intact transplant mice that were not cycling at the time of transplant surgery showed a life-span advantage over transplant mice that were still cycling at surgery (810.5 ± 21.8 vs 754.1 ± 16.1, respectively, p = .0481). This cycling effect was not seen in sham groups (non-cycling 729.5 ± 19.7 vs cycling 726.8 ± 21.2, p = .9250).Notes: IT = intact; S = sham; TX = ovarian transplant. *p = .05, **p < .05, ***p < .005.
Figure 6.
Figure 6.
Survival proportion in intact cycling vs non-cycling groups.Notes: IT = intact; S = sham; TX = ovarian transplant.

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