A pilot study revealing impaired P50 gating in antisocial personality disorder

J Neuropsychiatry Clin Neurosci. 2009 Summer;21(3):328-31. doi: 10.1176/jnp.2009.21.3.328.


The authors investigated preattentive filtering assessed by P50 gating in nine participants with antisocial personality disorder (ASPD) and seven with adult-onset antisocial behavior (AAB). Relative to 15 comparison subjects, gating was impaired in ASPD, suggesting abnormal pre-attentive filtering in pathological impulsivity.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acoustic Stimulation
  • Adult
  • Age of Onset
  • Analysis of Variance
  • Antisocial Personality Disorder / physiopathology*
  • Auditory Perception / physiology
  • Brain / physiopathology*
  • Electroencephalography
  • Evoked Potentials
  • Female
  • Humans
  • Male
  • Neuropsychological Tests
  • Pilot Projects
  • Time Factors