Partial mole with a diploid fetus: case study and literature review

Fetal Diagn Ther. 2009;25(3):354-8. doi: 10.1159/000235885. Epub 2009 Sep 22.


Objective: To describe an extremely rare case of a partial hydatidiform mole with a normal fetus. The etiology and clinical management of this entity are discussed.

Method: Case report.

Results: We describe a rare case of partial mole and a living fetus of diploid karyotype and biparental origin confirmed by flow cytometry and PCR techniques. No malformations were observed, beta-hCG levels were high (>100,000 mIU/ml) and persistent trophoblastic disease did eventually occur.

Conclusion: A suspected partial mole on ultrasound with increased beta-hCG and a sonographically normal living fetus of a diploid karyotype poses a dilemma for clinical management. Termination of pregnancy is not indicated if the fetus is normal; in fact, continuation to birth is possible in nearly 60% of cases with no increase in maternal risks when the patient is closely monitored after birth until beta-hCG is negative. In the case presented, however, a spontaneous abortion occurred at 21 weeks' gestation, possibly as a result of the amniocentesis.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Abortion, Spontaneous
  • Adult
  • Chorionic Gonadotropin, beta Subunit, Human / blood
  • Diploidy*
  • Female
  • Fetus
  • Humans
  • Hydatidiform Mole / blood
  • Hydatidiform Mole / diagnostic imaging*
  • Pregnancy
  • Ultrasonography


  • Chorionic Gonadotropin, beta Subunit, Human