The human aminopeptidase N gene: isolation, chromosome localization, and DNA polymorphism analysis

Hum Genet. 1990 Oct;85(6):651-4. doi: 10.1007/BF00193592.


DNA encoding the human aminopeptidase N (EC gene (PEPN) was first isolated using rat cDNA probes and then used in Southern analysis of DNA from mouse-human somatic cell hybrids to assign this gene to the long-arm region (q11-qter) of human chromosome 15. This human genomic DNA probe detects a frequent DraIII polymorphism that is a useful marker for human chromosome 15.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Aminopeptidases / genetics*
  • Animals
  • Base Sequence
  • Blotting, Southern
  • CD13 Antigens
  • Cells, Cultured
  • Chromosomes, Human, Pair 15
  • DNA / isolation & purification*
  • Humans
  • Hybrid Cells
  • In Vitro Techniques
  • Mice
  • Molecular Sequence Data
  • Polymorphism, Genetic*
  • Restriction Mapping


  • DNA
  • Aminopeptidases
  • CD13 Antigens