Bariatric surgery: what is the effect on type 2 diabetes?

Curr Opin Investig Drugs. 2009 Oct;10(10):1078-84.


Type 2 diabetes mellitus (T2DM) is a costly chronic disease that is associated with increased morbidity and mortality. Despite the development of numerous pharmacological agents, diet and exercise programs, and behavior-modification protocols, bariatric surgery remains the most effective tool for the durable reversal of T2DM. This review discusses the known effects of bariatric surgery on T2DM, with a particular focus on Roux-en-Y gastric bypass.

Publication types

  • Review

MeSH terms

  • Animals
  • Bariatric Surgery / methods*
  • Diabetes Mellitus, Type 2 / etiology
  • Diabetes Mellitus, Type 2 / physiopathology
  • Diabetes Mellitus, Type 2 / surgery*
  • Gastric Bypass / methods
  • Humans
  • Insulin Resistance
  • Insulin-Secreting Cells / metabolism
  • Obesity / complications
  • Obesity / surgery*