AhR and ARNT modulate ER signaling

Toxicology. 2010 Feb 9;268(3):132-8. doi: 10.1016/j.tox.2009.09.007. Epub 2009 Sep 22.

Abstract

The aryl hydrocarbon receptor (AhR), in complex with its binding partner ARNT, mediates the cellular response to xenobiotic compounds such as the environmental pollutant dioxin. In addition, the AhR has important regulatory roles in normal physiology. For instance, there is extensive data showing an intricate relationship between the AhR and estrogen receptor (ER) pathways. This review focuses on the regulatory roles of AhR and ARNT, beyond the response to xenobiotics. In particular, the effects of AhR agonists on the estrogen signaling pathways and the role of ARNT as a modulator of ER activity are discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Aryl Hydrocarbon Receptor Nuclear Translocator / agonists
  • Aryl Hydrocarbon Receptor Nuclear Translocator / antagonists & inhibitors
  • Aryl Hydrocarbon Receptor Nuclear Translocator / physiology*
  • Endocrine Disruptors / toxicity
  • Environmental Pollutants / toxicity
  • Humans
  • Methylcholanthrene / toxicity
  • Polychlorinated Dibenzodioxins / toxicity
  • Receptors, Aryl Hydrocarbon / agonists
  • Receptors, Aryl Hydrocarbon / antagonists & inhibitors
  • Receptors, Aryl Hydrocarbon / physiology*
  • Receptors, Estrogen / drug effects
  • Receptors, Estrogen / physiology*
  • Signal Transduction / physiology*
  • Xenobiotics / metabolism
  • Xenobiotics / toxicity*

Substances

  • ARNT protein, human
  • Endocrine Disruptors
  • Environmental Pollutants
  • Polychlorinated Dibenzodioxins
  • Receptors, Aryl Hydrocarbon
  • Receptors, Estrogen
  • Xenobiotics
  • Aryl Hydrocarbon Receptor Nuclear Translocator
  • Methylcholanthrene