Making strides in peptide-based therapeutics

Danielle A Guarracino; Paramjit S Arora

doi:10.1016/j.chembiol.2009.09.005

Making strides in peptide-based therapeutics

Chem Biol. 2009 Sep 25;16(9):919-20. doi: 10.1016/j.chembiol.2009.09.005.

Authors

Danielle A Guarracino¹, Paramjit S Arora

Affiliation

¹ Department of Chemistry, New York University, 100 Washington Square East, New York, NY 10003, USA.

PMID: 19778718
DOI: 10.1016/j.chembiol.2009.09.005

Abstract

In a recent report published in PNAS, Gellman and coworkers describe the design, characterization, and potent activity of alpha/beta-peptides that mimic a long alpha helix involved in HIV viral entry.

MeSH terms

HIV Envelope Protein gp41 / antagonists & inhibitors
HIV Envelope Protein gp41 / metabolism
HIV Fusion Inhibitors / chemistry
HIV Fusion Inhibitors / pharmacology*
Humans
Peptides, Cyclic / chemistry
Peptides, Cyclic / pharmacology*
Protein Interaction Domains and Motifs
Protein Structure, Secondary

Substances

HIV Envelope Protein gp41
HIV Fusion Inhibitors
Peptides, Cyclic