(R)-4-oxo-5-phosphononorvaline: A New Competitive Glutamate Antagonist at the NMDA Receptor Complex

J Med Chem. 1990 Nov;33(11):2961-3. doi: 10.1021/jm00173a009.

MeSH terms

  • Animals
  • Binding, Competitive
  • Cerebellum / drug effects
  • Cerebellum / metabolism
  • Cyclic GMP / metabolism
  • Excitatory Amino Acid Antagonists*
  • Glutamates / metabolism
  • Glutamic Acid
  • Kindling, Neurologic / drug effects
  • Mice
  • Mice, Inbred DBA
  • N-Methylaspartate / antagonists & inhibitors
  • N-Methylaspartate / metabolism*
  • N-Methylaspartate / pharmacology
  • Rats
  • Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors*
  • Receptors, N-Methyl-D-Aspartate / metabolism
  • Valine / analogs & derivatives*
  • Valine / chemical synthesis
  • Valine / chemistry
  • Valine / metabolism

Substances

  • Excitatory Amino Acid Antagonists
  • Glutamates
  • Receptors, N-Methyl-D-Aspartate
  • 4-oxo-5-phosphononorvaline
  • Glutamic Acid
  • N-Methylaspartate
  • Cyclic GMP
  • Valine