Acetylcholinesterase and HHV-8 in squamous cell carcinoma and retinoblastoma

In Vivo. 2009 Sep-Oct;23(5):679-83.

Abstract

Acetylcholinesterase (AChE) and human herpesvirus type 8 (HHV-8) antigens were studied in tissue sections from 56 squamous cell carcinomas (SCC) and five retinoblastomas (Rb). Approximately 62.5% of SCC and 80% of Rb showed positive staining for AChE. AChE staining in tumors was much higher than in normal control tissue. However, only 21.4% of SCC and 60% of Rb contained HHV-8 antigens. Of the 56 SCC, 17.9% were positive for both AChE and HHV-8 antigens, whereas 60% Rb were positive for both markers. The co-existence of AChE and HHV-8 antigens may play a role in the development of SCC and Rb. A possible mechanism for the development of these tumors is discussed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylcholinesterase / metabolism*
  • Carcinoma, Squamous Cell / epidemiology
  • Carcinoma, Squamous Cell / pathology*
  • Carcinoma, Squamous Cell / virology
  • Comorbidity
  • Herpesviridae Infections / complications
  • Herpesviridae Infections / epidemiology
  • Herpesviridae Infections / pathology*
  • Herpesvirus 8, Human / isolation & purification*
  • Herpesvirus 8, Human / physiology
  • Humans
  • Immunoenzyme Techniques
  • Retinal Neoplasms / epidemiology
  • Retinal Neoplasms / pathology*
  • Retinal Neoplasms / virology
  • Retinoblastoma / epidemiology
  • Retinoblastoma / pathology*
  • Retinoblastoma / virology
  • Saudi Arabia / epidemiology
  • Seroepidemiologic Studies

Substances

  • Acetylcholinesterase