Abstract
Acetylcholinesterase (AChE) and human herpesvirus type 8 (HHV-8) antigens were studied in tissue sections from 56 squamous cell carcinomas (SCC) and five retinoblastomas (Rb). Approximately 62.5% of SCC and 80% of Rb showed positive staining for AChE. AChE staining in tumors was much higher than in normal control tissue. However, only 21.4% of SCC and 60% of Rb contained HHV-8 antigens. Of the 56 SCC, 17.9% were positive for both AChE and HHV-8 antigens, whereas 60% Rb were positive for both markers. The co-existence of AChE and HHV-8 antigens may play a role in the development of SCC and Rb. A possible mechanism for the development of these tumors is discussed.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetylcholinesterase / metabolism*
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Carcinoma, Squamous Cell / epidemiology
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Carcinoma, Squamous Cell / pathology*
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Carcinoma, Squamous Cell / virology
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Comorbidity
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Herpesviridae Infections / complications
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Herpesviridae Infections / epidemiology
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Herpesviridae Infections / pathology*
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Herpesvirus 8, Human / isolation & purification*
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Herpesvirus 8, Human / physiology
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Humans
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Immunoenzyme Techniques
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Retinal Neoplasms / epidemiology
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Retinal Neoplasms / pathology*
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Retinal Neoplasms / virology
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Retinoblastoma / epidemiology
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Retinoblastoma / pathology*
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Retinoblastoma / virology
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Saudi Arabia / epidemiology
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Seroepidemiologic Studies