Association between oxidized LDL, obesity and type 2 diabetes in a population-based cohort, the Health, Aging and Body Composition Study

Diabetes Metab Res Rev. 2009 Nov;25(8):733-9. doi: 10.1002/dmrr.1011.

Abstract

Background: Accumulating evidence suggests a cross-sectional association between oxidative stress and type 2 diabetes (T2D). Systemic oxidative stress, as measured by oxidized LDL (oxLDL), has been correlated with visceral fat. We examined the relationship between oxLDL, and T2D- and obesity-related traits in a bi-racial sample of 2985 subjects at baseline and after 7 years of follow-up.

Methods: We examined six T2D-related traits (T2D status, HbA(1c), fasting glucose, insulin, adiponectin and HOMA-IR) as well as six obesity-related traits (obesity status, BMI, leptin, % body fat, visceral and subcutaneous fat mass) using logistic and linear regression models.

Results: In all subjects at baseline, oxLDL was positively associated with T2D (OR = 1.3, 95% CI:1.1-1.5), fasting glucose (ss = 0.03 +/- 0.006), HbA(1c) (ss = 0.02 +/- 0.004), fasting insulin (ss = 0.12 +/- 0.02), HOMA-IR (ss = 0.13 +/- 0.02) and negatively with adiponectin (ss = -0.16 +/- 0.03), (all p < 0.001). The strength and magnitude of these associations did not differ much between blacks and whites. In both blacks and whites, oxLDL was also associated with obesity (OR = 1.3, 95% CI:1.1-1.4) and three of its related traits (ss = 0.60 +/- 0.14 for BMI, ss = 0.74 +/- 0.17 for % body fat, ss = 0.29 +/- 0.06 for visceral fat; all p < 0.001). Furthermore, of four traits measured after 7 years of follow-up (fasting glucose, HbA1c, BMI and % fat), their relationship with oxLDL was similar to baseline observations. No significant association was found between oxLDL and incident T2D. Interestingly, oxLDL was significantly associated with % change in T2D- and obesity-related traits in whites but not in blacks.

Conclusion/interpretation: Our data suggest that systemic oxidative stress may be a novel risk factor for T2D and obesity.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adiponectin / blood
  • African Americans / statistics & numerical data
  • Aged
  • Blood Glucose / analysis
  • Body Composition
  • Body Mass Index
  • Diabetes Mellitus, Type 2 / blood
  • Diabetes Mellitus, Type 2 / complications*
  • Diabetes Mellitus, Type 2 / physiopathology
  • European Continental Ancestry Group / statistics & numerical data
  • Female
  • Glycated Hemoglobin A / analysis
  • Humans
  • Insulin / blood
  • Insulin Resistance
  • Leptin / blood
  • Lipoproteins, LDL / blood*
  • Male
  • Obesity / blood
  • Obesity / complications*
  • Obesity / physiopathology
  • Oxidation-Reduction
  • Predictive Value of Tests
  • Prospective Studies
  • Statistics as Topic
  • Surveys and Questionnaires
  • United States

Substances

  • Adiponectin
  • Blood Glucose
  • Glycated Hemoglobin A
  • Insulin
  • Leptin
  • Lipoproteins, LDL
  • hemoglobin A1c protein, human
  • oxidized low density lipoprotein