Endoplasmic reticulum stress in disease: mechanisms and therapeutic opportunities

Clin Sci (Lond). 2009 Sep 28;118(1):19-29. doi: 10.1042/CS20080680.


Various stresses, which impair ER (endoplasmic reticulum) function, lead to an accumulation of unfolded or misfolded proteins. ER stress triggers many rescuer responses, including a UPR (unfolded protein response). Increasing evidence has suggested that ER stress is involved in neurodegenerative diseases (Alzheimer's disease, Parkinson's disease and cerebral ischaemic insults), cancer, obesity and diabetes. In the present review, we consider the importance of ER stress under pathological conditions in mammals. Furthermore, we discuss the therapeutic potential for treatment targeting ER stress.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Diabetes Mellitus, Type 2 / drug therapy
  • Diabetes Mellitus, Type 2 / pathology
  • Diabetes Mellitus, Type 2 / physiopathology
  • Endoplasmic Reticulum / drug effects
  • Endoplasmic Reticulum / physiology*
  • Neoplasms / drug therapy
  • Neoplasms / pathology
  • Neoplasms / physiopathology
  • Neurodegenerative Diseases / drug therapy
  • Neurodegenerative Diseases / pathology*
  • Neurodegenerative Diseases / physiopathology
  • Obesity / pathology
  • Obesity / physiopathology
  • Protein Folding
  • Stress, Physiological / drug effects
  • Stress, Physiological / physiology*