Functional brain imaging in 14 patients with dissociative amnesia reveals right inferolateral prefrontal hypometabolism

Psychiatry Res. 2009 Oct 30;174(1):32-9. doi: 10.1016/j.pscychresns.2009.03.008. Epub 2009 Sep 23.


Dissociative amnesia is a condition usually characterized by severely impaired retrograde memory functioning in the absence of structural brain damage. Recent case studies nevertheless found functional brain changes in patients suffering from autobiographical-episodic memory loss in the cause of dissociative amnesia. Functional changes were demonstrated in both resting state and memory retrieval conditions. In addition, some but not all cases also showed other neuropsychological impairments beyond retrograde memory deficits. However, there is no group study available that examined potential functional brain abnormalities and accompanying neuropsychological deteriorations in larger samples of patients with dissociative retrograde amnesia. We report functional imaging and neuropsychological data acquired in 14 patients with dissociative amnesia following stressful or traumatic events. All patients suffered from autobiographical memory loss. In addition, approximately half of the patients had deficits in anterograde memory and executive functioning. Accompanying functional brain changes were measured by [18F]fluorodeoxyglucose positron emission tomography (FDG-PET). Regional glucose utilization of the patients was compared with that of 19 healthy subjects, matched for age and gender. We found significantly decreased glucose utilization in the right inferolateral prefrontal cortex in the patients. Hypometabolism in this brain region, known to be involved in retrieval of autobiographical memories and self-referential processing, may be a functional brain correlate of dissociative amnesia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Amnesia / diagnostic imaging*
  • Amnesia / pathology*
  • Amnesia / physiopathology
  • Brain Mapping*
  • Female
  • Fluorodeoxyglucose F18
  • Functional Laterality / physiology*
  • Humans
  • Image Processing, Computer-Assisted
  • Magnetic Resonance Imaging / methods
  • Male
  • Middle Aged
  • Neuropsychological Tests
  • Oxygen / blood
  • Positron-Emission Tomography / methods
  • Prefrontal Cortex / blood supply*
  • Prefrontal Cortex / diagnostic imaging*
  • Young Adult


  • Fluorodeoxyglucose F18
  • Oxygen