Abstract
As a novel example of improved entry of poorly delivered drugs into the brain by means of nutrient conjugates, L-carnitine was conjugated to nipecotic acid and the capacity to antagonize PTZ-induced convulsions of this novel entity was evaluated.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Brain / drug effects
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Brain / metabolism
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Carnitine / chemistry*
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Dose-Response Relationship, Drug
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Injections, Intraperitoneal
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Mice
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Nipecotic Acids / administration & dosage
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Nipecotic Acids / chemistry*
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Nipecotic Acids / pharmacology
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Nipecotic Acids / therapeutic use
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Prodrugs / administration & dosage
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Prodrugs / chemistry
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Prodrugs / pharmacology*
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Prodrugs / therapeutic use
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Seizures / drug therapy
Substances
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Nipecotic Acids
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Prodrugs
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nipecotic acid
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Carnitine