Region-specific neural induction of an engrailed protein by anterior notochord in Xenopus

Science. 1990 Nov 9;250(4982):800-2. doi: 10.1126/science.1978411.


Anterior-specific neural induction can be assayed by means of an antibody that recognizes the Xenopus homeobox-containing protein En-2. The En-2 antigen is an excellent early marker, since it is present as a discrete band in the anterior neural plate of neurula embryos. Regional induction was assayed by combining dorsal mesoderm with competent ectoderm. Anterior notochord from the early neurula induced En-2 frequently, while posterior notochord induced En-2 less frequently. Presumptive somitic mesoderm and presumptive head mesoderm, though they induced neural tissue, were not strong inducers of En-2. Thus, anterior notochord may be the primary mesodermal tissue responsible for the patterning of the anterior neural plate.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Gene Expression Regulation*
  • Genes, Homeobox*
  • Notochord / physiology*
  • Transcription Factors / blood*
  • Transcription Factors / genetics
  • Xenopus / embryology*
  • Xenopus / genetics


  • Transcription Factors