Coeliac disease associated with psoriasis

Br J Dermatol. 2009 Dec;161(6):1331-4. doi: 10.1111/j.1365-2133.2009.09398.x. Epub 2009 Jul 7.


Background: Psoriasis is a chronic inflammatory disorder of the skin reported to be associated with systemic comorbidities.

Objectives: To investigate the association between psoriasis and coeliac disease (CD).

Methods: Patients with psoriasis were compared with age- and sex-matched controls regarding the prevalence of CD in a case-control study. chi(2) and t-tests were used for univariate analysis and a logistic regression model was used for multivariate analysis. The study was performed utilizing the medical database of Clalit Health Services.

Results: The study included 12,502 patients with psoriasis aged > 20 years and 24,285 age- and sex-matched controls. The prevalence of CD in patients with psoriasis was increased compared with the prevalence in controls (0.29% and 0.11%, respectively, P < 0.001). In a multivariate analysis psoriasis was associated with CD (odds ratio 2.73, 95% confidence interval 1.65-4.53).

Conclusions: Patients with psoriasis have a greater prevalence of CD than matched controls. Recent studies showed a possibility of undiagnosed CD among patients with psoriasis. Therefore, physicians treating patients with psoriasis should be aware of this possible association.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Celiac Disease / complications*
  • Celiac Disease / epidemiology
  • Epidemiologic Methods
  • Female
  • Humans
  • Male
  • Middle Aged
  • Psoriasis / complications*
  • Psoriasis / epidemiology
  • Risk Factors
  • Severity of Illness Index
  • Young Adult