Abstract
Common variant single-nucleotide polymorphisms at the MHC locus have recently been associated with schizophrenia. Together with known associations with rare copy-number variants affecting many genes, this reveals the highly polygenic etiology of the disease.
MeSH terms
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Genetic Predisposition to Disease*
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Genetic Variation
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Genome-Wide Association Study
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Humans
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Major Histocompatibility Complex / genetics
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Meta-Analysis as Topic
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Multifactorial Inheritance / genetics*
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Polymorphism, Single Nucleotide*
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Proto-Oncogene Proteins / genetics
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Receptor, Notch4
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Receptors, Notch / genetics
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Schizophrenia / genetics*
Substances
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NOTCH4 protein, human
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Proto-Oncogene Proteins
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Receptor, Notch4
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Receptors, Notch