Clinical significance of multiple drug resistance in human cancers

Anticancer Res. 1990 Sep-Oct;10(5A):1297-302.

Abstract

This review summarizes the basic aspects of multidrug resistance (MDR). We first propose a brief reappraisal of the occurrence of MDR encoded P-glycoprotein, (P-g-P) in various normal and tumor tissues. We then present a series of studies undertaken to estimate the MDR1 gene expression or the presence of P-g-P in various human cancers. Finally, we conclude on the potential use of P-g-P measurements in some cancers as a useful if not powerful means of reversing clinical multidrug resistance.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • Drug Resistance / genetics*
  • Gene Expression
  • Glutathione Transferase / genetics
  • Humans
  • Membrane Glycoproteins / analysis
  • Membrane Glycoproteins / genetics*
  • Neoplasms / drug therapy*

Substances

  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • Membrane Glycoproteins
  • Glutathione Transferase