NMDA-dependent induction of long-term potentiation in afferent and association fiber systems of piriform cortex in vitro

Brain Res. 1990 Aug 13;525(1):175-9. doi: 10.1016/0006-8993(90)91337-g.


Long-term potentiation (LTP) was demonstrated in a slice preparation of piriform (olfactory) cortex. LTP could be reliably induced in both afferent and association fiber pathways. The magnitude of the observed potentiation was greater in the association fiber pathway. 2-Amino-5-phosphonovalerate (APV) blocked induction of LTP in both pathways, indicating that N-methyl-D-aspartate (NMDA) receptor activation is required for induction.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • 2-Amino-5-phosphonovalerate / pharmacology
  • Afferent Pathways / physiology
  • Animals
  • Cerebral Cortex / physiology*
  • Electric Stimulation
  • Evoked Potentials / physiology
  • In Vitro Techniques
  • Nerve Fibers / physiology*
  • Rats
  • Receptors, N-Methyl-D-Aspartate / drug effects
  • Receptors, N-Methyl-D-Aspartate / physiology*
  • Time Factors


  • Receptors, N-Methyl-D-Aspartate
  • 2-Amino-5-phosphonovalerate