Sulpiride in tardive dyskinesia

J Neurol Neurosurg Psychiatry. 1990 Sep;53(9):800-2. doi: 10.1136/jnnp.53.9.800.


The abnormal involuntary movements in tardive dyskinesia can be reduced by the dopamine antagonist drugs, phenothiazines and butyrophenones, but most cause an increase in Parkinsonian signs. Sulpiride, a benzamide derivative, and selective antagonist of D2 receptors had a significantly beneficial effect on most of 15 patients (p less than 0.01). In 12 patients the improvement was marked. The reduction of abnormal movements was observed even with low doses, and it was not necessary to increase the dose of sulpiride above 600 mg daily. There were no significant side effects during the trial nor during an additional three months of treatment.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Antipsychotic Agents / administration & dosage
  • Antipsychotic Agents / adverse effects*
  • Dyskinesia, Drug-Induced / drug therapy*
  • Female
  • Humans
  • Long-Term Care
  • Male
  • Middle Aged
  • Neurologic Examination
  • Schizophrenia / drug therapy*
  • Single-Blind Method
  • Sulpiride / administration & dosage*
  • Sulpiride / adverse effects


  • Antipsychotic Agents
  • Sulpiride