Microcystic adnexal carcinoma - aggressive infiltrative tumor often with innocent clinical appearance

J Dtsch Dermatol Ges. 2010 Apr;8(4):275-8. doi: 10.1111/j.1610-0387.2009.07254.x. Epub 2009 Sep 24.
[Article in English, German]


Microcystic adnexal carcinoma is a rare sweat gland malignancy, characterized by slow, but aggressive infiltrative growth. Histologic characteristics are follicular and glandular differentiation, as well as bland cytologic features. The benign histologic appearance, particularly in the upper level of the tumor, can be confused with syringoma or benign follicular neoplasm. Thus the risk of misdiagnosis is considerable, especially if only superficial biopsies are provided. We report two patients with microcystic adnexal carcinoma, using them as a basis to discuss, pathogenesis, diagnosis, histology and therapy of the tumor.

Publication types

  • Case Reports

MeSH terms

  • Adenoma
  • Adenoma, Sweat Gland / pathology*
  • Adenoma, Sweat Gland / surgery*
  • Aged
  • Facial Neoplasms / pathology*
  • Facial Neoplasms / surgery*
  • Humans
  • Male
  • Middle Aged
  • Mouth Neoplasms / pathology*
  • Mouth Neoplasms / surgery*
  • Treatment Outcome