Protein and energy metabolism in type 1 diabetes

Clin Nutr. 2010 Feb;29(1):13-7. doi: 10.1016/j.clnu.2009.09.001. Epub 2009 Sep 27.


Profound metabolic changes occur in people with type 1 diabetes mellitus during insulin deprivation. These include an increase in basal energy expenditure and reduced mitochondrial function. In addition, protein metabolism is significantly affected during insulin deprivation. A greater increase in whole-body protein breakdown than protein synthesis occurs resulting in a net protein loss. During insulin deprivation the splanchnic bed has a net protein accretion which accounts for the total increase in whole-body protein synthesis while muscle is in a net catabolic state.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Asia
  • Basal Metabolism
  • Diabetes Mellitus, Type 1 / metabolism*
  • Energy Metabolism*
  • Humans
  • Proteins / metabolism*


  • Proteins