The nursing profession historically has been involved in data collection in research efforts notably from the time of the Framingham Tuberculosis Project (1914-1923). Over the past century, nurses have become more sophisticated in their abilities to design, conduct, and analyze data. This article discusses the contributions of medicine and epidemiology to the development of public health nursing and the use of statistical methods by nurses in the United States in the 19th and 20th centuries. Knowledge acquired from this article will inform educators and researchers about the importance of using quantitative analysis, evidenced-based knowledge, and statistical methods when teaching students in all health professions.