An ancient, highly conserved family of cysteine-rich protein domains revealed by cloning type I and type II murine macrophage scavenger receptors

Proc Natl Acad Sci U S A. 1990 Nov;87(22):8810-4. doi: 10.1073/pnas.87.22.8810.


Scavenger receptors have been implicated in the development of atherosclerosis and other macrophage-associated functions. The bovine type I and type II scavenger receptors are multidomain transmembrane proteins that differ only by the presence in the type I receptor of an additional, extracellular cysteine-rich C-terminal domain. The isolation of type I and type II receptor cDNAs from a murine macrophage cell line, P388D1, establishes the presence of mRNAs encoding both receptor types in a single cell. Their sequences are highly similar to the bovine cDNAs. Receptor type-specific cDNA probes map to a common locus on murine chromosomes 8, suggesting that a single gene encodes both mRNAs. The type I-specific scavenger receptor cysteine-rich (SRCR) domain helps define a previously unrecognized family of remarkably well-conserved domains. Highly homologous SRCR domains (one, three, or four per polypeptide chain) are found in diverse secreted and cell-surface proteins from humans (e.g., CD5, complement factor I), mice (Ly-1), and sea urchins (speract receptor).

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cell Line
  • Chromosome Mapping
  • Cloning, Molecular
  • Cysteine
  • DNA / genetics
  • Macrophages
  • Membrane Proteins*
  • Mice
  • Molecular Sequence Data
  • Multigene Family
  • Oligonucleotides
  • Polymerase Chain Reaction
  • Polymorphism, Restriction Fragment Length
  • Receptors, Immunologic / genetics*
  • Receptors, Lipoprotein*
  • Receptors, Scavenger
  • Scavenger Receptors, Class A
  • Scavenger Receptors, Class B


  • Membrane Proteins
  • Msr1 protein, mouse
  • Oligonucleotides
  • Receptors, Immunologic
  • Receptors, Lipoprotein
  • Receptors, Scavenger
  • Scarb1 protein, mouse
  • Scavenger Receptors, Class A
  • Scavenger Receptors, Class B
  • DNA
  • Cysteine

Associated data

  • GENBANK/M36817
  • GENBANK/M36818
  • GENBANK/M59445
  • GENBANK/M59446