Quinine-induced disseminated intravascular coagulation

Lancet. 1990 Dec 22-29;336(8730):1535-7. doi: 10.1016/0140-6736(90)93309-d.


Recurrent disseminated intravascular coagulation occurred in 3 women after ingestion of quinine tablets for cramp. All had circulating quinine-dependent antibodies to platelets and in 2 there was initial evidence of antibody consumption, with low titres that rose steeply over the next few days and remained high for many months.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Aged
  • Disseminated Intravascular Coagulation / chemically induced*
  • Disseminated Intravascular Coagulation / immunology
  • Female
  • Humans
  • Muscle Cramp / drug therapy
  • Muscle Cramp / immunology
  • Quinine / adverse effects*
  • Quinine / immunology


  • Quinine