Quality of life in cirrhosis is related to potentially treatable factors

Eur J Gastroenterol Hepatol. 2010 Feb;22(2):221-7. doi: 10.1097/MEG.0b013e3283319975.


Objective: Improvement of prognosis and availability of diverse therapeutic options for complications of advanced liver disease highlight the importance of health-related quality of life (HRQOL) in cirrhosis. The aim of this study was to identify factors that influence HRQOL and may be potentially treatable in patients with cirrhosis.

Methods: HRQOL was measured in 212 outpatients with cirrhosis using a generic questionnaire (Medical Outcomes Study Form, SF-36) and a liver-specific questionnaire (Chronic Liver Disease Questionnaire, CLDQ). All patients underwent a systematic clinical and neuropsychological assessment. Independent factors associated with poor HRQOL were identified by multiple linear regression.

Results: HRQOL scores exhibited by patients were: global CLDQ: 4.8+/-1.2; Physical Component Score of SF-36: 38.5+/-10.7; Mental Component Score of SF-36: 45.3+/-14.3. The independent variables for global CLDQ were female sex, nonalcoholic etiology, current ascites, and a decrease in albumin (R = 0.22). For Physical Component Score of SF-36, the independent variables were prior hepatic encephalopathy, current ascites, and a decrease in hemoglobin (R = 0.22). For Mental Component Score of SF-36, the independent variables were nonalcoholic etiology, the Grooved Pegboard test, and a decrease in hemoglobin (R = 0.14).

Conclusion: Several clinical variables, potentially treatable, may alter particular aspects of HRQOL. Correction of ascites, hypoalbuminemia, minimal hepatic encephalopathy, and anemia may cause a positive impact on HRQOL of patients with cirrhosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Anemia / etiology
  • Anemia / psychology
  • Anemia / therapy
  • Ascites / etiology
  • Ascites / psychology
  • Ascites / therapy
  • Cross-Sectional Studies
  • Female
  • Hepatic Encephalopathy / etiology
  • Hepatic Encephalopathy / psychology
  • Hepatic Encephalopathy / therapy
  • Humans
  • Hypoalbuminemia / etiology
  • Hypoalbuminemia / psychology
  • Hypoalbuminemia / therapy
  • Linear Models
  • Liver Cirrhosis / complications
  • Liver Cirrhosis / diagnosis
  • Liver Cirrhosis / psychology*
  • Liver Cirrhosis / therapy*
  • Liver Failure / diagnosis
  • Liver Failure / etiology
  • Liver Failure / psychology*
  • Liver Failure / therapy*
  • Male
  • Middle Aged
  • Neuropsychological Tests
  • Quality of Life*
  • Risk Assessment
  • Risk Factors
  • Severity of Illness Index
  • Surveys and Questionnaires
  • Treatment Outcome