Comorbidity - A Troublesome Factor in PTSD Treatment

Psychiatr Danub. 2009 Sep;21(3):420-4.


Posttraumatic stress syndrome (PTSD) is a disorder which emerges after the patient has experienced one or more psychotraumatic events, which equally include neurobiological deregulation and psychological dysfunction. Comorbidity is present in more than 80% of the diagnosed cases of PTSD, which makes treatment of the primary disorder very difficult. It has been identified that PTSD can be found in comorbidity with other psychiatric disorders as well as with physical illnesses. This study presents aged 42, who has been psychiatrically treated for the past 12 years, with a diagnose of chronic PTSD and who subsequently developed depression. The patient has been treated for psoriasis for the past seven years, and two years ago, had to undergo surgery due to bladder carcinoma, followed by a radiotherapy course. Multiple comorbidity significantly makes the treatment of the primary illness very difficult and it limits the choice of pharmacotherapy in ambulatory conditions.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anti-Anxiety Agents / adverse effects
  • Anti-Anxiety Agents / therapeutic use*
  • Antidepressive Agents / adverse effects
  • Antidepressive Agents / therapeutic use*
  • Combat Disorders / drug therapy*
  • Combat Disorders / epidemiology*
  • Combined Modality Therapy
  • Comorbidity
  • Depressive Disorder / drug therapy
  • Depressive Disorder / epidemiology*
  • Diazepam / adverse effects
  • Diazepam / therapeutic use*
  • Drug Eruptions / diagnosis
  • Drug Eruptions / epidemiology
  • Drug Therapy, Combination
  • Humans
  • Male
  • Personality Inventory / statistics & numerical data
  • Psoriasis / diagnosis
  • Psoriasis / epidemiology*
  • Psychometrics
  • Psychotherapy
  • Urinary Bladder Neoplasms / diagnosis
  • Urinary Bladder Neoplasms / epidemiology*


  • Anti-Anxiety Agents
  • Antidepressive Agents
  • Diazepam