Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies

Nat Rev Drug Discov. 2009 Oct;8(10):783-93. doi: 10.1038/nrd2959.


Neuronal inclusions comprised of the microtubule-associated protein tau are found in numerous neurodegenerative diseases, commonly known as tauopathies. In Alzheimer's disease - the most prevalent tauopathy - misfolded tau is probably a key pathological agent. The recent failure of amyloid-beta-targeted therapeutics in Phase III clinical trials suggests that it is timely and prudent to consider alternative drug discovery strategies for Alzheimer's disease. Here, we focus on strategies directed at reducing misfolded tau and compensating for the loss of normal tau function.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alzheimer Disease / drug therapy*
  • Alzheimer Disease / metabolism
  • Alzheimer Disease / pathology
  • Animals
  • Drug Discovery / methods
  • Drug Discovery / trends*
  • Humans
  • Tauopathies / drug therapy*
  • Tauopathies / metabolism
  • Tauopathies / pathology
  • tau Proteins* / antagonists & inhibitors
  • tau Proteins* / metabolism


  • tau Proteins