Multiple sclerosis. TNFRSF1A, TRAPS and multiple sclerosis

Tania Kümpfel; Reinhard Hohlfeld

doi:10.1038/nrneurol.2009.154

Multiple sclerosis. TNFRSF1A, TRAPS and multiple sclerosis

Nat Rev Neurol. 2009 Oct;5(10):528-9. doi: 10.1038/nrneurol.2009.154.

Authors

Tania Kümpfel¹, Reinhard Hohlfeld

Affiliation

¹ Institute of Clinical Neuroimmunology-Campus Grosshadern, Ludwig Maximilians University of Munich, Marchioninistrasse 15, Munich, Germany. tania.kuempfel@med.uni-muenchen.de

PMID: 19794511
DOI: 10.1038/nrneurol.2009.154

Abstract

A genome-wide association study has identified the R92Q variant of the TNFRSF1A gene as a new susceptibility locus for multiple sclerosis. This locus is of special interest because the R92Q substitution was previously detected in a group of multiple sclerosis patients who had additional symptoms compatible with the autoinflammatory syndrome TRAPS.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Autoimmune Diseases / genetics*
Autoimmune Diseases / immunology
Genetic Predisposition to Disease*
Genome-Wide Association Study
Humans
Multiple Sclerosis / genetics*
Multiple Sclerosis / immunology
Receptors, Tumor Necrosis Factor / genetics
Receptors, Tumor Necrosis Factor / immunology
Receptors, Tumor Necrosis Factor, Type I / genetics*
Receptors, Tumor Necrosis Factor, Type I / immunology
Signal Transduction / genetics
Signal Transduction / immunology
Syndrome
Tumor Necrosis Factor-alpha / genetics
Tumor Necrosis Factor-alpha / immunology

Substances

Receptors, Tumor Necrosis Factor
Receptors, Tumor Necrosis Factor, Type I
TNFRSF1A protein, human
Tumor Necrosis Factor-alpha