Multiple sclerosis. TNFRSF1A, TRAPS and multiple sclerosis

Nat Rev Neurol. 2009 Oct;5(10):528-9. doi: 10.1038/nrneurol.2009.154.


A genome-wide association study has identified the R92Q variant of the TNFRSF1A gene as a new susceptibility locus for multiple sclerosis. This locus is of special interest because the R92Q substitution was previously detected in a group of multiple sclerosis patients who had additional symptoms compatible with the autoinflammatory syndrome TRAPS.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Autoimmune Diseases / genetics*
  • Autoimmune Diseases / immunology
  • Genetic Predisposition to Disease*
  • Genome-Wide Association Study
  • Humans
  • Multiple Sclerosis / genetics*
  • Multiple Sclerosis / immunology
  • Receptors, Tumor Necrosis Factor / genetics
  • Receptors, Tumor Necrosis Factor / immunology
  • Receptors, Tumor Necrosis Factor, Type I / genetics*
  • Receptors, Tumor Necrosis Factor, Type I / immunology
  • Signal Transduction / genetics
  • Signal Transduction / immunology
  • Syndrome
  • Tumor Necrosis Factor-alpha / genetics
  • Tumor Necrosis Factor-alpha / immunology


  • Receptors, Tumor Necrosis Factor
  • Receptors, Tumor Necrosis Factor, Type I
  • TNFRSF1A protein, human
  • Tumor Necrosis Factor-alpha