Acoustomotive optical coherence elastography for measuring material mechanical properties

Opt Lett. 2009 Oct 1;34(19):2894-6. doi: 10.1364/OL.34.002894.

Abstract

Acoustomotive optical coherence elastography (AM-OCE), a dynamic and internal excitation optical coherence elastography technique, is reported. Acoustic radiation force was used for internal mechanical excitation, and spectral-domain optical coherence tomography was used for detection. Mechanical properties of gelatin tissue phantoms were measured by AM-OCE and verified using rheometry results. Measured mechanical properties including shear moduli and shear damping parameters of the gelatin samples double when their polymer concentration increases from 3% to 4%. Spectral analysis was also performed on the acquired data, which improved the processing speed by a factor of 5 compared with a least-square fitting approach. Quantitative measurement, microscale resolution, and remote excitation are the main features of AM-OCE, which make the technique promising for measuring biomechanical properties.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Acoustics*
  • Animals
  • Biomechanical Phenomena
  • Biophysics / methods
  • Elasticity Imaging Techniques / methods
  • Equipment Design
  • Gelatin / chemistry
  • Humans
  • Optics and Photonics
  • Phantoms, Imaging
  • Polymers / chemistry
  • Rheology / methods
  • Stress, Mechanical
  • Tomography, Optical Coherence / methods*

Substances

  • Polymers
  • Gelatin