This paper reviews thin-layer chromatographic, high-performance liquid chromatographic, gas chromatographic and gas chromatographic-mass spectrometric procedures for the identification and quantification of sixty histamine H1- and ten H2-receptor blockers in biosamples, published from 1984 to 1989. The biomedical importance of the published procedures and consequences for their choice, the sample preparation and the chromatography itself are discussed. The fundamental information about the biosample assayed, work-up, stationary and mobile phase, detection mode and sensitivity of each procedure is summarized in seven tables. They are arranged according to the chromatographic method and the category of histamine receptor blockers. Examples of typical chromatographic separations are presented in three figures.