The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily

Nature. 1990 Dec 20-27;348(6303):693-9. doi: 10.1038/348693a0.


The let-23 gene is required for induction of the Caenorhabditis elegans vulva. It is shown that let-23 encodes a putative tyrosine kinase of the epidermal growth factor receptor subfamily. Thus, let-23 might encode the receptor for the inductive signal required for vulval development. Because let-23 acts upstream of let-60 ras in the vulval determination pathway, the identification of the let-23 product provides support for a link in vivo between tyrosine kinase growth factor receptors and ras proteins in a pathway of cell-type determination.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Caenorhabditis / enzymology
  • Caenorhabditis / genetics*
  • Caenorhabditis / growth & development
  • Cloning, Molecular
  • DNA / genetics
  • DNA / isolation & purification
  • ErbB Receptors / genetics*
  • Female
  • Genes, ras
  • Humans
  • Molecular Sequence Data
  • Nucleic Acid Hybridization
  • Polymerase Chain Reaction
  • Polymorphism, Restriction Fragment Length
  • Protein-Tyrosine Kinases / genetics*
  • RNA, Messenger / analysis
  • Restriction Mapping
  • Sequence Homology, Nucleic Acid
  • Vulva / growth & development


  • RNA, Messenger
  • DNA
  • ErbB Receptors
  • Protein-Tyrosine Kinases