Genetic inactivation of Ikaros is a rare event in human T-ALL

Leuk Res. 2010 Apr;34(4):426-9. doi: 10.1016/j.leukres.2009.09.012. Epub 2009 Sep 30.


The Ikaros (Ikzf1) gene, encoding a transcription regulator, is a major tumor suppressor in B-cell acute lymphoblastic leukemia (B-ALL). In the mouse, however, loss of Ikaros is primarily associated with T-ALL development. Whether Ikaros is also implicated in human T-ALL remains unclear. We studied Ikaros in 25 human T-ALL samples from diverse molecular subtypes at the mRNA, protein, sequence and genomic copy number level. We found that Ikaros was abnormal in only one sample: one allele was lost by genomic deletion, while proteins generated from the remaining allele were delocalized and concentrated at a single cytoplasmic structure. Thus, inactivation of Ikaros by deletion or mutation is rare in human T-ALL.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Child
  • Child, Preschool
  • Cohort Studies
  • Comparative Genomic Hybridization
  • Gene Deletion
  • Gene Expression Regulation, Leukemic
  • Gene Silencing* / physiology
  • Humans
  • Ikaros Transcription Factor / genetics*
  • Ikaros Transcription Factor / physiology
  • Infant
  • Jurkat Cells
  • Middle Aged
  • Mutation / physiology
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / genetics*
  • Protein Isoforms / genetics
  • Young Adult


  • IKZF1 protein, human
  • Protein Isoforms
  • Ikaros Transcription Factor