Antinociceptive activity of lectins from Diocleinae seeds on acetic acid-induced writhing test in mice

Protein Pept Lett. 2009;16(9):1088-92. doi: 10.2174/092986609789055304.

Abstract

Diocleinae lectins administered per oral route in mice inhibited the abdominal constrictions induced by acetic acid. The percentage of the lectins antinociception varied from 61% for Canavalia grandiflora (ConGf) to 20% for Dioclea violacea. ConGf inhibited contortions at all doses tested but not in a dose-dependent manner, involving carbohydrate recognition.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetic Acid
  • Analgesics / pharmacology*
  • Animals
  • Dioclea / chemistry
  • Female
  • Male
  • Mice
  • Pain / chemically induced
  • Plant Lectins / pharmacology*
  • Seeds / chemistry

Substances

  • Analgesics
  • Plant Lectins
  • Acetic Acid