Longitudinal assessment of antimüllerian hormone during pregnancy-relationship with maternal adiposity, insulin, and adiponectin

Fertil Steril. 2010 Mar 1;93(4):1356-8. doi: 10.1016/j.fertnstert.2009.07.1676. Epub 2009 Oct 1.

Abstract

We examined in a prospective longitudinal pregnancy cohort the influence of advancing gestation and baseline maternal adiposity on antimüllerian hormone (AMH) and determined whether maternal hormones (insulin, leptin, adiponectin, E(2), and sex hormone-binding globulin) correlate with alterations in AMH. We demonstrate that first-trimester AMH is associated negatively with maternal adiposity, that circulating levels decline during the second and third trimesters of pregnancy, and that in univariate and multivariate models adiponectin is associated positively with AMH during this period of pregnancy-related decline.

Publication types

  • Comparative Study

MeSH terms

  • Adiponectin / blood*
  • Adiposity / physiology*
  • Anti-Mullerian Hormone / blood*
  • Cohort Studies
  • Female
  • Humans
  • Insulin / blood*
  • Insulin Resistance / physiology
  • Longitudinal Studies
  • Maternal Welfare / trends
  • Pregnancy
  • Prospective Studies

Substances

  • Adiponectin
  • Insulin
  • Anti-Mullerian Hormone