The excitatory amino acid antagonist amino-phosphono-valeric acid (APV) provides protection against penicillin-induced epileptic activity in the rat

C Loeb; A Patrone; G Besio; M Balestrino; P Mainardi

doi:10.1016/0920-1211(90)90080-f

The excitatory amino acid antagonist amino-phosphono-valeric acid (APV) provides protection against penicillin-induced epileptic activity in the rat

Epilepsy Res. 1990 Aug;6(3):249-51. doi: 10.1016/0920-1211(90)90080-f.

Authors

C Loeb¹, A Patrone, G Besio, M Balestrino, P Mainardi

Affiliation

¹ Department of Neurology, University of Genoa, Italy.

PMID: 1980246
DOI: 10.1016/0920-1211(90)90080-f

Abstract

The effects of intraperitoneal injection of 2-amino-5-phosphono-valeric acid (APV) on EEG-monitored penicillin-induced epileptic activity in rats were evaluated. A significant decrease in the frequency of spikes occurred with low APV dosages (10 and 20 mg/kg), while an almost complete disappearance of spike activity was observed at higher APV doses (40 and 160 mg/kg). Our data suggest that excitatory amino acids play a relevant role in penicillin-induced epileptic activity in rats.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

2-Amino-5-phosphonovalerate / therapeutic use*
Animals
Electroencephalography / drug effects
Epilepsy / chemically induced
Epilepsy / drug therapy*
Male
Motor Activity / drug effects
Penicillins / antagonists & inhibitors
Rats
Rats, Inbred Strains

Substances

Penicillins
2-Amino-5-phosphonovalerate