Digestive and nutritional considerations in celiac disease: could supplementation help?

Altern Med Rev. 2009 Sep;14(3):247-57.


Due to the increased immune activation in the intestinal tract of people with celiac disease, the digestive and absorptive processes of those affected may be compromised. Individuals with celiac disease are more susceptible to pancreatic insufficiencies, dysbiosis, lactase insufficiencies, and folic acid, vitamin B12, iron, and vitamin D deficiencies, as well as accelerated bone loss due to an increase in inflammatory signaling molecules. Beyond strict maintenance of a gluten-free diet, research has shown benefit with additional nutritional supplementation to assist in regulation of several of these complications.

Publication types

  • Review

MeSH terms

  • Anemia, Iron-Deficiency / drug therapy
  • Anemia, Iron-Deficiency / etiology
  • Celiac Disease / complications
  • Celiac Disease / drug therapy*
  • Dietary Supplements*
  • Exocrine Pancreatic Insufficiency / drug therapy
  • Exocrine Pancreatic Insufficiency / etiology
  • Folic Acid / therapeutic use*
  • Humans
  • Iron, Dietary / therapeutic use*
  • Lactose Intolerance / drug therapy
  • Lactose Intolerance / etiology
  • Nutritional Support
  • Vitamin B 12 / therapeutic use*
  • Vitamin D / therapeutic use*


  • Iron, Dietary
  • Vitamin D
  • Folic Acid
  • Vitamin B 12