Three isostructural solvates of finasteride and their solid-state characterization

Eur J Pharm Sci. 2009 Dec 8;38(5):498-503. doi: 10.1016/j.ejps.2009.09.014. Epub 2009 Oct 3.

Abstract

Three crystalline hemi-hydrate, channel solvates (classified as solvates from here on) of finasteride (N-(1,1-di-methylethyl)-3-oxo-4-aza-5 alpha-androst-1-ene-17beta-carboxamide) have been obtained and fully characterized. The acetone, methyl ethyl ketone (MEK), and toluene solvates of finasteride, described herein, were found to be isostructural and belong as additional members to a family of previously reported finasteride solvates. Vacuum drying at 85 degrees C for 1 day produced the metastable, anhydrous Form II of finasteride from all three solvated materials.

Publication types

  • Comparative Study

MeSH terms

  • Chemistry, Pharmaceutical / methods*
  • Finasteride / analysis
  • Finasteride / chemistry*
  • Pharmaceutical Solutions / chemistry
  • Solubility
  • Solvents
  • Stereoisomerism
  • X-Ray Diffraction / methods

Substances

  • Pharmaceutical Solutions
  • Solvents
  • Finasteride