Treatment outcomes among pulmonary tuberculosis patients at treatment centers in Ibadan, Nigeria

Ann Afr Med. 2009 Apr-Jun;8(2):100-4. doi: 10.4103/1596-3519.56237.


Objective: To assess treatment outcomes and determinants of outcome among tuberculosis patients.

Design: A longitudinal study design involving a cohort of sputum smear-positive pulmonary tuberculosis patients at initiation of therapy, who were followed up to the end of treatment at eighth month.

Setting: Tuberculosis treatment centers in Ibadan, Nigeria.

Results: A total of 1,254 patients were followed up with a mean age of 35.0+/-3.3 years. The percentages of patients with treatment outcomes assessed in the study were as follows: cure (76.6%), failure (8.1%), default (6.6%), transferred out (4.8%), and death (1.9%). The cure rate varied significantly between treatment centers from 40 to 94.4% (P<0.05). The treatment centers located within the specialist health centers at Jericho and the University College Hospital had 50 and 75% cure rates, respectively.The mean age of cured patients was 31.2+/3.1 years which was significantly lower than the mean age of those with poor treatment outcomes (36.7+/3.5 years; P<0.05). Males had a higher risk of a poor treatment outcome (RR=1.8; 95% CI: 1.02-1.94) than females. Also, patients with a poor knowledge of tuberculosis had a higher risk of having a poor treatment outcome (RR=1.35; 95% CI: 1.25-1.62) compared to those with knowledge.

Conclusion: Variations in health center treatment outcomes and poor knowledge of tuberculosis among patients suggest that poor program implementation quality may be a major modifiable determinant of treatment outcomes in our environment.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Adult
  • Female
  • Hospitals, Chronic Disease
  • Humans
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Nigeria / epidemiology
  • Risk
  • Risk Assessment
  • Sputum / chemistry
  • Treatment Outcome
  • Tuberculosis, Pulmonary / epidemiology
  • Tuberculosis, Pulmonary / therapy*
  • Young Adult