Chromosomal instability: a composite phenotype that influences sensitivity to chemotherapy

Cell Cycle. 2009 Oct 15;8(20):3262-6. doi: 10.4161/cc.8.20.9690. Epub 2009 Oct 31.


Chromosomal instability (CIN) is defined as continual gain or loss of whole chromosomes or fractions of chromosomes and is a major cause of the genomic instability that characterizes most solid tumors. CIN is associated with intrinsic resistance to taxanes, acquired multidrug resistance and poor prognosis in many solid tumors, although recent evidence has shown that platinum agents, such as carboplatin, may specifically target CIN cancers.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antineoplastic Agents / pharmacology
  • Cell Line, Tumor
  • Chromosomal Instability*
  • Chromosome Segregation
  • Drug Resistance, Neoplasm
  • Humans
  • Kinetochores
  • Mitosis
  • Neoplasms / drug therapy
  • Taxoids / pharmacology


  • Antineoplastic Agents
  • Taxoids