Cerebellar degeneration and ocular myasthenia gravis in a patient with recurring ovarian carcinoma

Neurol Sci. 2010 Feb;31(1):79-81. doi: 10.1007/s10072-009-0154-3. Epub 2009 Oct 6.

Abstract

Myasthenia gravis (MG) and paraneoplastic cerebellar degeneration (PCD) are immune-mediated syndromes that can represent paraneoplastic disorders. We report a patient with history of ovarian carcinoma that presented with ptosis, diplopia and gait ataxia. Neurophysiological examination and laboratory tests revealed the presence of MG and PCD. An integrated FDG-PET/contrast-enhanced CT scan showed tumor recurrence. This is to the best of our knowledge the first association of MG and PCD with recurring ovarian carcinoma.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Carcinoma / diagnostic imaging
  • Carcinoma / pathology*
  • Female
  • Humans
  • Myasthenia Gravis / diagnostic imaging
  • Myasthenia Gravis / pathology*
  • Neoplasm Recurrence, Local
  • Ovarian Neoplasms / diagnostic imaging
  • Ovarian Neoplasms / pathology*
  • Paraneoplastic Cerebellar Degeneration / diagnostic imaging
  • Paraneoplastic Cerebellar Degeneration / pathology*
  • Positron-Emission Tomography
  • Tomography, X-Ray Computed