A fenugreek seed extract selectively reduces spontaneous fat consumption in healthy volunteers

Eur J Clin Pharmacol. 2009 Dec;65(12):1175-8. doi: 10.1007/s00228-009-0733-5. Epub 2009 Oct 7.


Purpose: Fenugreek seeds (Trigonella foenum-graecum L.) are an old herbal remedy used to treat metabolic and nutritive dysfunctions. They have been shown to modulate feeding behaviour in animals, but strong clinical data are lacking. The aim of this study was to investigate the effects of a repeated administration of a fenugreek seed extract on energy intake and eating behaviour in healthy human volunteers.

Methods: Twelve healthy male volunteers completed a double-blind randomized placebo-controlled three-period cross-over trial of two different doses of a fenugreek seed extract (588 and 1176 mg). The three 14-day treatment periods were separated by a 14-day washout period. The main endpoints were energy intake, assessed in volunteers under normal ambulatory and free-living conditions by a 3-day detailed dietary record and during a meal test, weight, fasting glucose level, insulin and lipid profile, visual analogue scale scores of appetite/satiety and blood glucose and insulin levels measured repeatedly after a standardized breakfast.

Results: Daily fat consumption was significantly decreased by the higher dose of fenugreek seed extract [3.73 vs. 4.51 MJ day(-1), -17.3% vs. placebo, 95% confidence interval (CI) -1.51 to -0.05, n = 12, P = 0.038]. This specific reduction tended to lower the total energy intake (9.97 vs. 11.29 MJ day(-1), -11.7% vs. placebo, 95% CI -2.91 to 0.26, n = 12, P = 0.094). No significant effect was observed on the other nutrients or other endpoints.

Conclusions: The repeated administration of a fenugreek seed extract specifically decreases dietary fat consumption in humans which, given the traditional use of the plant, constitutes a novel result.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Blood Glucose / drug effects
  • Body Weight / drug effects
  • Cross-Over Studies
  • Double-Blind Method
  • Energy Intake / drug effects*
  • Fats / metabolism*
  • Feeding Behavior / drug effects*
  • Humans
  • Hypoglycemic Agents / pharmacology*
  • Insulin / blood
  • Lipid Metabolism / drug effects
  • Male
  • Placebos
  • Plant Extracts / pharmacology*
  • Seeds / chemistry
  • Trigonella / chemistry*
  • Young Adult


  • Blood Glucose
  • Fats
  • Hypoglycemic Agents
  • Insulin
  • Placebos
  • Plant Extracts
  • fenugreek seed meal