Somatostatin receptor imaging in vivo localization of tumors with a radiolabeled somatostatin analog

J Steroid Biochem Mol Biol. 1990 Dec 20;37(6):1079-82. doi: 10.1016/0960-0760(90)90469-2.


This paper presents the results of the visualization of somatostatin (SS) receptor positive tumors in man after the i.v. administration of the SS analog Tyr3-octreotide coupled to 123I. It is an easy, quick and harmless procedure which allows imaging of primary and (often unexpected) secondary deposits and/or multiple localizations of the majority of endocrine pancreatic tumors, metastatic carcinoids and pituitary tumors, as well as of a multitude of tumors with neuroendocrine characteristics and well-differentiated brain tumors and meningiomas. In the case of hormone-secreting tumors a positive scan in most instances also predicts the subsequent successful therapy with octreotide.

Publication types

  • Review

MeSH terms

  • Humans
  • Iodine Radioisotopes
  • Pancreatic Neoplasms / secondary
  • Pancreatic Neoplasms / ultrastructure*
  • Pituitary Neoplasms / secondary
  • Pituitary Neoplasms / ultrastructure*
  • Receptors, Neurotransmitter / ultrastructure*
  • Receptors, Somatostatin
  • Somatostatin / analysis*


  • Iodine Radioisotopes
  • Receptors, Neurotransmitter
  • Receptors, Somatostatin
  • Somatostatin