Benign liver-cell adenoma associated with long-term administration of an androgenic-anabolic steroid (methandienone)

Cancer. 1977 Oct;40(4):1761-4. doi: 10.1002/1097-0142(197710)40:4<1761::aid-cncr2820400454>;2-c.


A 19-year-old man with paroxysmal nocturnal hemoglobinuria treated for 3 years with Methandienone was admitted to the hospital with hemoperitoneum due to the rupture of an hepatic tumor. Histology revealed that it was a benign liver cell adenoma, with a pathologic appearance and mode of clinical presentation closely resembling those of cases observed to develop in association to contraceptive steroids.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Carcinoma, Hepatocellular / chemically induced*
  • Hemoglobinuria, Paroxysmal / drug therapy
  • Humans
  • Liver Neoplasms / chemically induced*
  • Male
  • Methandrostenolone / adverse effects*


  • Methandrostenolone