Do B cells play a role in the pathogenesis of juvenile idiopathic arthritis?

Autoimmunity. 2009 May;42(4):373-5. doi: 10.1080/08916930902832306.


Juvenile idiopathic arthritis (JIA) is the most common cause of chronic arthritis in childhood and adolescents and encompasses a heterogeneous group of diseases. The role of B cells (BC) in autoimmune diseases has been put in a new perspective due to the promising results of BC depleting therapies in RA. Experiments in mouse models have shed new light on the Ab-independent role of BC in the pathogenesis of autoimmune diseases. We discuss whether BC play a role in the pathogenesis of JIA appraising the question for an immunological basis of BC directed therapy.

Publication types

  • Review

MeSH terms

  • Adolescent
  • Animals
  • Arthritis, Juvenile / immunology*
  • B-Lymphocytes / immunology*
  • Child
  • Humans
  • Mice