Molecular mechanisms of viral immune evasion proteins to inhibit MHC class I antigen processing and presentation

Int Rev Immunol. 2009;28(5):376-93. doi: 10.1080/08830180903013034.


Viral products inhibit MHC class I antigen processing and presentation via three major pathways: inhibition of major histocompatibility complex (MHC) class I expression on cells, blockade of peptide trafficking and loading on MHC class I molecules, and inhibition of peptide generation in host cells. Viral products also interfere with IFN-gamma -mediated JAK/STAT signal transduction in cells. These results imply that viral proteins probably inhibit the function of IFN-gamma in MHC class I antigen presentation via inactivation of JAK/STAT signal transduction in host cells. Mechanisms of viral products to inhibit IFN-gamma -mediated MHC class I antigen presentation were summarized in this literature review.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigen Presentation / immunology*
  • Histocompatibility Antigens Class I / immunology*
  • Humans
  • Immune Evasion / immunology*
  • Signal Transduction / immunology*
  • Viral Proteins / immunology*


  • Histocompatibility Antigens Class I
  • Viral Proteins