Molecular mechanisms of IFN-gamma to up-regulate MHC class I antigen processing and presentation

Int Rev Immunol. 2009;28(3-4):239-60. doi: 10.1080/08830180902978120.


IFN-gamma up-regulates MHC class I expression and antigen processing and presentation on cells, since IFN-gamma can induce multiple gene expressions that are related to MHC class I antigen processing and presentation. MHC class I antigen presentation-associated gene expression is initiated by IRF-1. IRF-1 expression is initiated by phosphorylated STAT1. IFN-gamma binds to IFN receptors, and then activates JAK1/JAK2/STAT1 signal transduction via phosphorylation of JAK and STAT1 in cells. IFN-gamma up-regulates MHC class I antigen presentation via activation of JAK/STAT1 signal transduction pathway. Mechanisms of IFN-gamma to enhance MHC class I antigen processing and presentation were summarized in this literature review.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigen Presentation / immunology*
  • Gene Expression
  • Gene Expression Regulation / immunology
  • Histocompatibility Antigens Class I / immunology*
  • Histocompatibility Antigens Class I / metabolism
  • Humans
  • Interferon-gamma / immunology*
  • Interferon-gamma / metabolism
  • Signal Transduction / immunology*
  • Up-Regulation


  • Histocompatibility Antigens Class I
  • Interferon-gamma