What Does the Retrosplenial Cortex Do?

Nat Rev Neurosci. 2009 Nov;10(11):792-802. doi: 10.1038/nrn2733. Epub 2009 Oct 8.

Abstract

The past decade has seen a transformation in research on the retrosplenial cortex (RSC). This cortical area has emerged as a key member of a core network of brain regions that underpins a range of cognitive functions, including episodic memory, navigation, imagination and planning for the future. It is now also evident that the RSC is consistently compromised in the most common neurological disorders that impair memory. Here we review advances on multiple fronts, most notably in neuroanatomy, animal studies and neuroimaging, that have highlighted the importance of the RSC for cognition, and consider why specifying its precise functions remains problematic.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Anterior Thalamic Nuclei / physiology*
  • Cerebral Cortex / anatomy & histology
  • Cerebral Cortex / physiology*
  • Cognition / physiology*
  • Gyrus Cinguli / anatomy & histology
  • Gyrus Cinguli / physiology*
  • Humans
  • Nerve Net / anatomy & histology
  • Nerve Net / physiology