Prolonged compound muscle action potential duration in critical illness myopathy

Muscle Nerve. 2009 Dec;40(6):1040-2. doi: 10.1002/mus.21445.


Critical illness myopathy (CIM) is a frequent cause of generalized weakness in the intensive care unit. Prolonged compound muscle action potential (CMAP) durations have been described in this patient population, and this study presents further data on CMAP duration in normal controls and patients with CIM. The findings highlight the importance of testing multiple nerve muscle combinations in weak, critically ill patients. Recognition of this pattern, which has not been widely described, can facilitate the diagnosis of CIM.

MeSH terms

  • Action Potentials*
  • Adult
  • Aged
  • Aged, 80 and over
  • Critical Illness
  • Electromyography
  • Humans
  • Middle Aged
  • Muscle Weakness / diagnosis*
  • Muscle, Skeletal / physiopathology*